Lynch Syndrome documents and resources for clinicians

On this page you will find Lynch Syndrome information and guidance documents, management guidelines and protocols, templates for patient letters and family history taking and patient information on colorectal and endometrial cancers.

How should I use these documents?

There are a number of template documents on this page which contain information that can be used by any Trust across the East Midlands and East of England.

However, you will need to download the document(s) you wish to use and apply your own Trust template and branding, including logo and any local contact information. These documents are clearly marked out by the following image:

Templates bearing this image need to be put into your own NHS Trust templates/branding.

Testing guidance and protocols

Testing strategies for Lynch syndrome in people with endometrial cancer (NICE diagnostics guidance DG42)

Endometrial Cancer Lynch Syndrome Testing Protocol (CUH)

Management guidleines

The following management guidelines have been produced by the UK Cancer Genetics Group (opens in a new tab).

Gene-specific management guidelines for Lynch Syndrome

MLH1 Mutation Carriers

MSH2 Mutation Carriers

MSH6 Mutation Carriers

PMS2 Mutation Carriers

Record of discussion form

LYNCH Record of discussion form v1 2023

Patient letter templates

Genetics result template letters for Lynch testing through mainstreaming pathway:

Tumor tissues suggestive of Lynch

Pathogenic variant identified

Variant of unknown significance

No variant identified

Family History Form

Family History Form regarding a family history of cancer

Patient Information

Information for patients with endometrial cancer

LYNCH Patient information leaflet - Colorectal Cancer v1 2023